What happens to Systemic Vascular Resistance (SVR) during septic shock?

During septic shock, Systemic Vascular Resistance (SVR) decreases due to the widespread vasodilation caused by the release of inflammatory mediators such as cytokines. In septic shock, the body undergoes a profound response to infection, leading to vasodilation in the systemic circulation. This response is primarily driven by the release of substances such as nitric oxide and prostaglandins which promote the relaxation of vascular smooth muscle.

As a result of this vasodilation, the vessels become larger, allowing for greater blood flow and decreased resistance to blood flow through the systemic circulation. This decrease in SVR is a hallmark of septic shock and is critical to understand in the context of the pathophysiology underlying the condition, as it impacts blood pressure and organ perfusion. Maintaining an awareness of SVR in septic patients can inform treatment strategies aimed at restoring hemodynamic stability.