What is the recommended dosage of Diphenhydramine for managing anaphylaxis in children?

Diphenhydramine, an antihistamine, is used in managing anaphylaxis to relieve symptoms caused by the release of histamine. The recommended dosage for children is 1 mg/kg administered intravenously (IV), up to a maximum of 25 mg per dose. This dosing is considered effective for reducing symptoms of allergic reactions and providing comfort to the patient after the acute phase of anaphylaxis has been addressed, typically with epinephrine as the first line of treatment.

Using 1 mg/kg IV allows for effective management while minimizing the risk of adverse effects associated with larger dosages. It is crucial to note that while diphenhydramine plays a role in addressing secondary symptoms, it is not a substitute for epinephrine, which is the primary treatment for severe anaphylaxis.

Other dosage options presented are either higher than the recommended threshold for safety or suggest routes of administration that are not routinely used as the first intervention in anaphylaxis. Understanding the appropriate dosing is vital for ensuring both efficacy and safety in pediatric patients experiencing such acute allergic reactions.