What is the role of Factor 13 in clotting?

Factor 13 plays a crucial role in the coagulation process by stabilizing fibrin clots. Once fibrin is formed during the clotting cascade, Factor 13 is activated (by thrombin) and cross-links the fibrin molecules, which strengthens the clot and prevents it from being easily broken down. This stabilization is vital for maintaining hemostasis, especially in preventing excessive bleeding and ensuring that the clot remains intact until tissue repair occurs. The integrity of the clot ensures that it can effectively function as a barrier to blood loss while allowing the healing process to take place within the injury site.